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In addition we provide a compilation of effects of CsA and FK506 on gene expression at the level of transcription. We further concentrate on the major known effect of these immunosuppressants, namely the inhibition of the PP2B phosphatase calcineurin. This review briefly describes these effects on signal transduction. CsA and FK506 selectively interact with certain cellular signal transduction pathways. Although identification of the involvement of the transcription factor NF-AT was an important step forward (6), it has become clear that immunosuppressant action is more complex. Yet despite their advantages both CsA and FK506 display unwanted side effects and a possible preference of one drug over another remains controversial (4, 5). (2) as a novel immuno-suppressant and its introduction into clinics in 1989 (3) extended the available regimen for immunosuppressive therapy. CsA has become a first choice drug for patients with allograft organs.

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The isolation of Cyclosporin A (CsA) from cultures of the fungus Tolypocladium inflatum and its subsequent elucidation of immunosuppressive properties by Borel et al. Del Sol Solize Color-Changing Unisex Sunglasses - Theres No Other - Changes Color from Silver to Graphite in the Sun - Polarized Pro 100 UVA/UVB Protection UPC.

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